Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1771135..1771783 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N4838_RS07660 Protein ID WP_262961155.1
Coordinates 1771598..1771783 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4838_RS07655 Protein ID WP_112308281.1
Coordinates 1771135..1771548 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS07630 (N4838_007645) 1766450..1767586 - 1137 WP_164455470.1 M4 family metallopeptidase -
N4838_RS07635 (N4838_007650) 1767745..1768662 - 918 WP_004264888.1 oxygen-dependent coproporphyrinogen oxidase -
N4838_RS07640 (N4838_007655) 1768799..1769230 + 432 WP_004264887.1 GNAT family acetyltransferase -
N4838_RS07645 (N4838_007660) 1769322..1769927 + 606 WP_050763802.1 RpoE-regulated lipoprotein -
N4838_RS07650 (N4838_007665) 1770170..1771069 + 900 WP_094961722.1 Dyp-type peroxidase -
N4838_RS07655 (N4838_007670) 1771135..1771548 - 414 WP_112308281.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4838_RS07660 (N4838_007675) 1771598..1771783 - 186 WP_262961155.1 type II toxin-antitoxin system HicA family toxin Toxin
N4838_RS07665 (N4838_007680) 1772106..1773128 + 1023 WP_196732342.1 sulfate ABC transporter substrate-binding protein -
N4838_RS07670 (N4838_007685) 1773128..1773958 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
N4838_RS07675 (N4838_007690) 1773958..1774818 + 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
N4838_RS07680 (N4838_007695) 1774821..1775909 + 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7020.21 Da        Isoelectric Point: 11.1711

>T278786 WP_262961155.1 NZ_CP123251:c1771783-1771598 [Providencia rettgeri]
VQSSELINILQKNGWKLERIRGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15390.36 Da        Isoelectric Point: 4.6719

>AT278786 WP_112308281.1 NZ_CP123251:c1771548-1771135 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAVAARKELKKTD

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References