Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 884717..885363 Replicon chromosome
Accession NZ_CP123251
Organism Providencia rettgeri strain YZLc5-3

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag N4838_RS03800 Protein ID WP_004905417.1
Coordinates 884717..884920 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag N4838_RS03805 Protein ID WP_004905413.1
Coordinates 884995..885363 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4838_RS03775 (N4838_003780) 880793..881131 + 339 WP_004905421.1 P-II family nitrogen regulator -
N4838_RS03780 (N4838_003785) 881181..882428 + 1248 WP_164456268.1 ammonium transporter AmtB -
N4838_RS03785 (N4838_003790) 882567..883436 - 870 WP_036958583.1 acyl-CoA thioesterase II -
N4838_RS03790 (N4838_003795) 883675..884133 + 459 WP_004905418.1 YbaY family lipoprotein -
N4838_RS03800 (N4838_003805) 884717..884920 - 204 WP_004905417.1 HHA domain-containing protein Toxin
N4838_RS03805 (N4838_003810) 884995..885363 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
N4838_RS03810 (N4838_003815) 885887..887257 - 1371 WP_094962148.1 murein transglycosylase D -
N4838_RS03815 (N4838_003820) 887339..888094 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
N4838_RS03820 (N4838_003825) 888135..888869 + 735 WP_094962149.1 methyltransferase domain-containing protein -
N4838_RS03825 (N4838_003830) 888866..889336 - 471 WP_004905405.1 ribonuclease HI -
N4838_RS03830 (N4838_003835) 889391..890152 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T278784 WP_004905417.1 NZ_CP123251:c884920-884717 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT278784 WP_004905413.1 NZ_CP123251:c885363-884995 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References