Detailed information of TA system TA027878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 661743..662319
• Replicon: plasmid pTM1
• Accession: NC_017957
• Organism: Tistrella mobilis KA081020-065

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3TTA7
• Locus tag: TMO_RS20770
• Protein ID: WP_014747672.1
• Coordinates: 661743..662033 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3TTA8
• Locus tag: TMO_RS20775
• Protein ID: WP_014747673.1
• Coordinates: 662020..662319 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TMO_RS31805	657482..657718	+	237	WP_014747668.1	acyl carrier protein	-
TMO_RS29815	657730..658665	-	936	WP_014747669.1	class I SAM-dependent methyltransferase	-
TMO_RS20760	658770..660806	+	2037	WP_014747670.1	HAD-IIIC family phosphatase	-
TMO_RS20765	660836..661741	-	906	WP_014747671.1	LysR family transcriptional regulator	-
TMO_RS20770	661743..662033	-	291	WP_014747672.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TMO_RS20775	662020..662319	-	300	WP_014747673.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TMO_RS20780	662739..666431	+	3693	WP_014747675.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..692456	692456

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10850.47 Da
• Isoelectric Point: 7.3163

>T27878 WP_014747672.1 NC_017957:c662033-661743 [Tistrella mobilis KA081020-065]
VPGLEWRETARADLLAIVDYISDHNPDAAQRLKDDIEARVAQLPMHPRLYRVGPVPGTREMLVRSNYLVIYQETPRAVIV
LRVLHGAQQWPPVSGS

Nucleotide

• Length: 291 bp

>T27878 NC_017957:c662033-661743 [Tistrella mobilis KA081020-065]
GTGCCCGGTCTTGAATGGCGGGAGACCGCGCGGGCGGACCTTCTGGCGATCGTCGATTACATCTCGGATCACAATCCGGA
TGCTGCGCAGCGTCTGAAGGATGATATCGAGGCCAGGGTTGCCCAGCTCCCGATGCATCCGCGTCTTTACAGGGTCGGGC
CTGTTCCAGGCACCCGGGAAATGCTCGTGCGATCGAATTATCTGGTGATTTATCAGGAAACACCCCGTGCGGTGATTGTT
CTACGCGTGCTTCATGGTGCCCAACAGTGGCCACCGGTATCCGGAAGCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11109.70 Da
• Isoelectric Point: 6.4735

>AT27878 WP_014747673.1 NC_017957:c662319-662020 [Tistrella mobilis KA081020-065]
MPARTTMLHIRVDEQLKAEATETLADLGLTVSDAVRILLTRVVRDKALPASLTANPEAYDAWFRAKVLEALDDDRPAVSH
DRVMDEAQALIDRKRRARS

Nucleotide

• Length: 300 bp

>AT27878 NC_017957:c662319-662020 [Tistrella mobilis KA081020-065]
ATGCCCGCCCGAACCACCATGCTCCATATCCGTGTTGACGAGCAGCTGAAGGCCGAGGCGACCGAAACGCTTGCGGATCT
GGGCCTGACCGTCTCTGATGCCGTTCGGATTCTGCTGACCCGTGTGGTCCGCGACAAGGCGCTCCCCGCCAGCCTGACCG
CGAACCCGGAGGCCTATGATGCCTGGTTCCGAGCGAAGGTTCTGGAGGCATTGGACGACGATCGGCCGGCGGTGTCGCAC
GACCGGGTGATGGACGAGGCTCAGGCACTGATCGACAGGAAGCGCCGTGCCCGGTCTTGA

Structures

Toxin

• AlphaFold DB: I3TTA7

Antitoxin

• AlphaFold DB: I3TTA8