Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4321018..4321515 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name ghoT Uniprot ID A0A163EQM5
Locus tag N4691_RS20570 Protein ID WP_001672275.1
Coordinates 4321018..4321191 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N4691_RS20575 Protein ID WP_000398619.1
Coordinates 4321219..4321515 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS20560 (4317688) 4317688..4319145 + 1458 WP_021557456.1 dipeptide/tripeptide permease DtpC -
N4691_RS20565 (4319382) 4319382..4320899 + 1518 WP_001295074.1 lysine--tRNA ligase -
N4691_RS20570 (4321018) 4321018..4321191 - 174 WP_001672275.1 type V toxin-antitoxin system toxin GhoT Toxin
N4691_RS20575 (4321219) 4321219..4321515 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N4691_RS20580 (4321742) 4321742..4322014 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N4691_RS20585 (4322026) 4322026..4322256 - 231 WP_021557455.1 4Fe-4S mono-cluster protein YjdI -
N4691_RS20590 (4322437) 4322437..4324068 + 1632 WP_001216477.1 sensor histidine kinase -
N4691_RS20595 (4324065) 4324065..4324784 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6569.09 Da        Isoelectric Point: 10.2288

>T278773 WP_001672275.1 NZ_CP123244:c4321191-4321018 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278773 WP_000398619.1 NZ_CP123244:c4321515-4321219 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163EQM5

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References