Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4223324..4223919 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name chpB Uniprot ID A0A8S7NE19
Locus tag N4691_RS20060 Protein ID WP_044189483.1
Coordinates 4223324..4223674 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N4691_RS20065 Protein ID WP_001223208.1
Coordinates 4223668..4223919 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS20040 (4218770) 4218770..4219792 - 1023 WP_001313531.1 ABC transporter permease -
N4691_RS20045 (4219806) 4219806..4221308 - 1503 WP_062892934.1 sugar ABC transporter ATP-binding protein -
N4691_RS20050 (4221448) 4221448..4222404 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N4691_RS20055 (4222714) 4222714..4223244 + 531 WP_000055075.1 inorganic diphosphatase -
N4691_RS20060 (4223324) 4223324..4223674 - 351 WP_044189483.1 endoribonuclease toxin ChpB Toxin
N4691_RS20065 (4223668) 4223668..4223919 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N4691_RS20070 (4224131) 4224131..4224472 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N4691_RS20075 (4224475) 4224475..4228254 - 3780 WP_062892753.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12541.47 Da        Isoelectric Point: 5.6219

>T278772 WP_044189483.1 NZ_CP123244:c4223674-4223324 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASSHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT278772 WP_001223208.1 NZ_CP123244:c4223919-4223668 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References