Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3488997..3489615 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4691_RS16610 Protein ID WP_001291435.1
Coordinates 3489397..3489615 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4691_RS16605 Protein ID WP_000344800.1
Coordinates 3488997..3489371 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS16595 (3484086) 3484086..3485279 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4691_RS16600 (3485302) 3485302..3488451 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N4691_RS16605 (3488997) 3488997..3489371 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4691_RS16610 (3489397) 3489397..3489615 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N4691_RS16615 (3489786) 3489786..3490337 + 552 WP_000102564.1 maltose O-acetyltransferase -
N4691_RS16620 (3490453) 3490453..3490923 + 471 WP_000136192.1 YlaC family protein -
N4691_RS16625 (3491087) 3491087..3492637 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4691_RS16630 (3492679) 3492679..3493032 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N4691_RS16640 (3493411) 3493411..3493722 + 312 WP_000409911.1 MGMT family protein -
N4691_RS16645 (3493753) 3493753..3494325 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278769 WP_001291435.1 NZ_CP123244:3489397-3489615 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278769 WP_000344800.1 NZ_CP123244:3488997-3489371 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References