Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 948970..949624 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag N4691_RS04630 Protein ID WP_000244777.1
Coordinates 949217..949624 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N4691_RS04625 Protein ID WP_000354046.1
Coordinates 948970..949236 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS04605 (945058) 945058..946491 - 1434 WP_021557183.1 6-phospho-beta-glucosidase BglA -
N4691_RS04610 (946536) 946536..946847 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N4691_RS04615 (947011) 947011..947670 + 660 WP_000250274.1 hemolysin III family protein -
N4691_RS04620 (947747) 947747..948727 - 981 WP_001625883.1 tRNA-modifying protein YgfZ -
N4691_RS04625 (948970) 948970..949236 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N4691_RS04630 (949217) 949217..949624 + 408 WP_000244777.1 protein YgfX Toxin
N4691_RS04635 (949664) 949664..950185 - 522 WP_001055874.1 flavodoxin FldB -
N4691_RS04640 (950297) 950297..951193 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N4691_RS04645 (951218) 951218..951928 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4691_RS04650 (951934) 951934..953667 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T278761 WP_000244777.1 NZ_CP123244:949217-949624 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278761 WP_000354046.1 NZ_CP123244:948970-949236 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References