Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 287899..288530 Replicon chromosome
Accession NZ_CP123244
Organism Escherichia coli strain YZMc3-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag N4691_RS01260 Protein ID WP_001259382.1
Coordinates 287899..288174 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N4691_RS01265 Protein ID WP_000593555.1
Coordinates 288171..288530 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4691_RS01245 (282903) 282903..283970 + 1068 WP_000361517.1 HlyD family efflux transporter periplasmic adaptor subunit -
N4691_RS01250 (283967) 283967..286702 + 2736 WP_262940680.1 ribosome-associated ATPase/putative transporter RbbA -
N4691_RS01255 (286702) 286702..287826 + 1125 WP_021557290.1 ABC transporter permease -
N4691_RS01260 (287899) 287899..288174 + 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
N4691_RS01265 (288171) 288171..288530 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4691_RS01270 (288580) 288580..289440 - 861 WP_021557289.1 class II aldolase -
N4691_RS01275 (289472) 289472..289741 - 270 WP_000933060.1 HPr family phosphocarrier protein -
N4691_RS01280 (289731) 289731..291239 - 1509 WP_021557288.1 FGGY-family carbohydrate kinase -
N4691_RS01285 (291232) 291232..292590 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
N4691_RS01290 (292667) 292667..292948 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N4691_RS01295 (292945) 292945..293418 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T278758 WP_001259382.1 NZ_CP123244:287899-288174 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT278758 WP_000593555.1 NZ_CP123244:288171-288530 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References