Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 106041..106666 Replicon plasmid pYZLc1-3_160k
Accession NZ_CP123241
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4725_RS25805 Protein ID WP_000911313.1
Coordinates 106268..106666 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag N4725_RS25800 Protein ID WP_000450520.1
Coordinates 106041..106268 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS25800 (106041) 106041..106268 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4725_RS25805 (106268) 106268..106666 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
N4725_RS25810 (106675) 106675..108828 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
N4725_RS25815 (109081) 109081..109812 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
N4725_RS25820 (109844) 109844..110341 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA12 / aadA2 / qacE / mph(A) / aph(3')-Ia / aac(3)-IId / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..160923 160923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T278754 WP_000911313.1 NZ_CP123241:106268-106666 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT278754 WP_000450520.1 NZ_CP123241:106041-106268 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References