Detailed information of TA system TA027875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3276302..3276848
• Replicon: chromosome
• Accession: NC_017956
• Organism: Tistrella mobilis KA081020-065

Toxin (Protein)

• Gene name: parE
• Uniprot ID: I3TPW1
• Locus tag: TMO_RS14920
• Protein ID: WP_014746476.1
• Coordinates: 3276302..3276601 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: TMO_RS14925
• Protein ID: WP_145978146.1
• Coordinates: 3276591..3276848 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TMO_RS14895	3272249..3272707	+	459	WP_014746471.1	Lrp/AsnC family transcriptional regulator	-
TMO_RS14900	3272807..3273718	+	912	WP_014746472.1	transglutaminase family protein	-
TMO_RS14905	3273870..3274793	+	924	WP_014746473.1	NAD(P)-dependent oxidoreductase	-
TMO_RS14910	3274745..3275620	-	876	WP_081598939.1	AraC family transcriptional regulator	-
TMO_RS14915	3275668..3276291	+	624	WP_014746475.1	LysE family transporter	-
TMO_RS14920	3276302..3276601	-	300	WP_014746476.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TMO_RS14925	3276591..3276848	-	258	WP_145978146.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
TMO_RS14930	3276931..3277476	-	546	WP_014746478.1	cysteine hydrolase	-
TMO_RS14935	3277598..3278584	+	987	WP_014746479.1	helix-turn-helix domain-containing protein	-
TMO_RS14945	3279122..3279430	+	309	WP_014746480.1	50S ribosomal protein L21	-
TMO_RS14950	3279545..3279805	+	261	WP_014746481.1	50S ribosomal protein L27	-
TMO_RS14955	3280029..3281519	+	1491	WP_014746482.1	GTPase ObgE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11411.25 Da
• Isoelectric Point: 9.4035

>T27875 WP_014746476.1 NC_017956:c3276601-3276302 [Tistrella mobilis KA081020-065]
MGYELSRAAVEDILAAYAYGMAQFGVRQAEDYQAGLSRLLLLIGEHPEMGRVRPEFRPPVRMLGYRRHVIVYTRRPDGNV
FVLRLLHGRQDIERLLADL

Nucleotide

• Length: 300 bp

>T27875 NC_017956:c3276601-3276302 [Tistrella mobilis KA081020-065]
ATGGGCTATGAGCTTTCGCGTGCTGCGGTAGAAGATATCCTCGCCGCTTACGCCTACGGAATGGCTCAATTCGGCGTCCG
TCAGGCGGAAGACTATCAGGCGGGCCTTTCGCGCCTTCTGCTTTTGATCGGGGAGCATCCGGAAATGGGGCGGGTCCGCC
CCGAGTTCAGGCCGCCGGTCCGTATGCTGGGGTATCGCCGTCACGTGATCGTCTATACGCGACGGCCGGACGGGAACGTG
TTCGTTCTGCGCCTCCTCCACGGGCGGCAGGATATCGAGCGTCTTCTCGCAGACCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9371.48 Da
• Isoelectric Point: 4.7420

>AT27875 WP_145978146.1 NC_017956:c3276848-3276591 [Tistrella mobilis KA081020-065]
MATMNVSVTDQMKIWVEGQVESGRYGNASDYIRDLIRRDQERRAALADIQRLIDEGLASGSSGLSMQDVLTEARRRAALS
ADNGL

Nucleotide

• Length: 258 bp

>AT27875 NC_017956:c3276848-3276591 [Tistrella mobilis KA081020-065]
ATGGCGACGATGAATGTGTCGGTCACCGACCAGATGAAGATCTGGGTGGAAGGACAGGTCGAGAGCGGGCGGTACGGAAA
CGCCAGCGACTATATAAGAGACCTCATCCGACGGGATCAGGAACGCAGGGCCGCACTTGCCGACATCCAGCGCCTGATAG
ACGAGGGATTGGCGAGCGGCAGCAGCGGCCTGTCCATGCAGGACGTGCTGACGGAAGCTCGGCGGCGGGCTGCTCTGTCG
GCAGACAATGGGCTATGA

Structures

Toxin

• AlphaFold DB: I3TPW1