Detailed information of TA system TA278742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3959838..3961527
• Replicon: chromosome
• Accession: NZ_CP123240
• Organism: Escherichia coli strain YZLc1-3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: N4725_RS19165
• Protein ID: WP_000365809.1
• Coordinates: 3959838..3960758 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: N4725_RS19170
• Protein ID: WP_001550661.1
• Coordinates: 3960745..3961527 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4725_RS19150 (3955928)	3955928..3957055	-	1128	WP_001550663.1	MFS transporter	-
N4725_RS19155 (3957197)	3957197..3958255	-	1059	WP_122987197.1	alpha/beta hydrolase	-
N4725_RS19160 (3958520)	3958520..3959404	+	885	WP_001119037.1	LysR family transcriptional regulator	-
N4725_RS19165 (3959838)	3959838..3960758	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N4725_RS19170 (3960745)	3960745..3961527	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
N4725_RS19175 (3961843)	3961843..3965052	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
N4725_RS19180 (3965399)	3965399..3965869	+	471	WP_000201185.1	hypothetical protein	-
N4725_RS19185 (3965866)	3965866..3965968	+	103	Protein_3756	helix-turn-helix domain-containing protein	-
N4725_RS19190 (3966060)	3966060..3966218	+	159	Protein_3757	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3958520..4015283	56763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T278742 WP_000365809.1 NZ_CP123240:c3960758-3959838 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT278742 WP_001550661.1 NZ_CP123240:c3961527-3960745 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0