Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3754812..3755430 Replicon chromosome
Accession NZ_CP123240
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4725_RS18200 Protein ID WP_001291435.1
Coordinates 3755212..3755430 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4725_RS18195 Protein ID WP_000344800.1
Coordinates 3754812..3755186 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS18185 (3749901) 3749901..3751094 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4725_RS18190 (3751117) 3751117..3754266 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
N4725_RS18195 (3754812) 3754812..3755186 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4725_RS18200 (3755212) 3755212..3755430 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N4725_RS18205 (3755602) 3755602..3756153 + 552 WP_000102564.1 maltose O-acetyltransferase -
N4725_RS18210 (3756269) 3756269..3756739 + 471 WP_000136192.1 YlaC family protein -
N4725_RS18215 (3756903) 3756903..3758453 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4725_RS18220 (3758495) 3758495..3758848 - 354 WP_001550741.1 DUF1428 family protein -
N4725_RS18230 (3759227) 3759227..3759538 + 312 WP_000409911.1 MGMT family protein -
N4725_RS18235 (3759569) 3759569..3760141 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278741 WP_001291435.1 NZ_CP123240:3755212-3755430 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278741 WP_000344800.1 NZ_CP123240:3754812-3755186 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References