Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3297179..3297884 Replicon chromosome
Accession NZ_CP123240
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N4725_RS16055 Protein ID WP_000539521.1
Coordinates 3297179..3297565 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N4725_RS16060 Protein ID WP_001280945.1
Coordinates 3297555..3297884 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS16035 (3293183) 3293183..3293809 + 627 WP_001595548.1 glutathione S-transferase GstB -
N4725_RS16040 (3293806) 3293806..3294921 - 1116 WP_106475077.1 aldose sugar dehydrogenase YliI -
N4725_RS16045 (3295032) 3295032..3295415 - 384 WP_000497137.1 biofilm formation regulator BssR -
N4725_RS16050 (3295628) 3295628..3296953 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
N4725_RS16055 (3297179) 3297179..3297565 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4725_RS16060 (3297555) 3297555..3297884 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N4725_RS16065 (3297954) 3297954..3299282 - 1329 WP_000086872.1 GGDEF domain-containing protein -
N4725_RS16070 (3299290) 3299290..3301368 - 2079 WP_106475076.1 EAL domain-containing protein -
N4725_RS16080 (3302130) 3302130..3302414 - 285 Protein_3151 CHASE9 sensor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T278740 WP_000539521.1 NZ_CP123240:3297179-3297565 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT278740 WP_001280945.1 NZ_CP123240:3297555-3297884 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References