Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3042969..3043753 Replicon chromosome
Accession NZ_CP123240
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag N4725_RS14855 Protein ID WP_000613626.1
Coordinates 3043259..3043753 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag N4725_RS14850 Protein ID WP_001110447.1
Coordinates 3042969..3043262 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS14840 (3038119) 3038119..3039078 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
N4725_RS14845 (3039651) 3039651..3042836 + 3186 WP_001550951.1 ribonuclease E -
N4725_RS14850 (3042969) 3042969..3043262 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
N4725_RS14855 (3043259) 3043259..3043753 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
N4725_RS14860 (3043848) 3043848..3044801 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
N4725_RS14865 (3044813) 3044813..3046456 - 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
N4725_RS14870 (3046522) 3046522..3047463 - 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
N4725_RS14875 (3047463) 3047463..3048560 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T278739 WP_000613626.1 NZ_CP123240:3043259-3043753 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT278739 WP_001110447.1 NZ_CP123240:3042969-3043262 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References