Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1023632..1024286 Replicon chromosome
Accession NZ_CP123240
Organism Escherichia coli strain YZLc1-3

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N4725_RS05035 Protein ID WP_000244781.1
Coordinates 1023879..1024286 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N4725_RS05030 Protein ID WP_000354046.1
Coordinates 1023632..1023898 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4725_RS05010 (1019720) 1019720..1021153 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
N4725_RS05015 (1021198) 1021198..1021509 + 312 WP_001598596.1 N(4)-acetylcytidine aminohydrolase -
N4725_RS05020 (1021673) 1021673..1022332 + 660 WP_000250269.1 hemolysin III family protein -
N4725_RS05025 (1022409) 1022409..1023389 - 981 WP_001562036.1 tRNA-modifying protein YgfZ -
N4725_RS05030 (1023632) 1023632..1023898 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N4725_RS05035 (1023879) 1023879..1024286 + 408 WP_000244781.1 protein YgfX Toxin
N4725_RS05040 (1024326) 1024326..1024847 - 522 WP_001055874.1 flavodoxin FldB -
N4725_RS05045 (1024959) 1024959..1025855 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
N4725_RS05050 (1025880) 1025880..1026590 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4725_RS05055 (1026596) 1026596..1028329 + 1734 WP_001598594.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T278729 WP_000244781.1 NZ_CP123240:1023879-1024286 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278729 WP_000354046.1 NZ_CP123240:1023632-1023898 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References