Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 65249..65874 Replicon plasmid pMB7355_1
Accession NZ_CP123238
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QET42_RS23685 Protein ID WP_000911313.1
Coordinates 65476..65874 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QET42_RS23680 Protein ID WP_000450520.1
Coordinates 65249..65476 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS23680 (65249) 65249..65476 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
QET42_RS23685 (65476) 65476..65874 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
QET42_RS23690 (65883) 65883..68036 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
QET42_RS23695 (68289) 68289..69020 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
QET42_RS23700 (69052) 69052..69549 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 / ant(3'')-Ia / sul3 / lnu(F) / sitABCD iutA / iucD / iucC / iucB / iucA 1..122596 122596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T278725 WP_000911313.1 NZ_CP123238:65476-65874 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT278725 WP_000450520.1 NZ_CP123238:65249-65476 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References