Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4026447..4027023 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QET42_RS19850 Protein ID WP_001297643.1
Coordinates 4026736..4027023 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QET42_RS19845 Protein ID WP_000063156.1
Coordinates 4026447..4026749 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS19830 (4023043) 4023043..4025193 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QET42_RS19835 (4025243) 4025243..4025446 + 204 WP_000467859.1 YbdD/YjiX family protein -
QET42_RS19840 (4025457) 4025457..4026413 + 957 WP_001297640.1 GTPase -
QET42_RS19845 (4026447) 4026447..4026749 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QET42_RS19850 (4026736) 4026736..4027023 - 288 WP_001297643.1 BrnT family toxin Toxin
QET42_RS19855 (4027222) 4027222..4027919 - 698 Protein_3882 IS1 family transposase -
QET42_RS19860 (4027976) 4027976..4028071 + 96 Protein_3883 dienelactone hydrolase family protein -
QET42_RS19865 (4028217) 4028217..4029449 + 1233 WP_001380906.1 multidrug efflux MFS transporter MdtM -
QET42_RS19870 (4029490) 4029490..4030770 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T278718 WP_001297643.1 NZ_CP123237:c4027023-4026736 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT278718 WP_000063156.1 NZ_CP123237:c4026749-4026447 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References