Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3508833..3509451 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QET42_RS17355 Protein ID WP_001291435.1
Coordinates 3509233..3509451 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QET42_RS17350 Protein ID WP_000344800.1
Coordinates 3508833..3509207 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS17340 (3503922) 3503922..3505115 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QET42_RS17345 (3505138) 3505138..3508287 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QET42_RS17350 (3508833) 3508833..3509207 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QET42_RS17355 (3509233) 3509233..3509451 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QET42_RS17360 (3509623) 3509623..3510174 + 552 WP_000102564.1 maltose O-acetyltransferase -
QET42_RS17365 (3510290) 3510290..3510760 + 471 WP_000136192.1 YlaC family protein -
QET42_RS17370 (3510924) 3510924..3512474 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QET42_RS17375 (3512516) 3512516..3512869 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QET42_RS17385 (3513248) 3513248..3513559 + 312 WP_000409911.1 MGMT family protein -
QET42_RS17390 (3513590) 3513590..3514162 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278715 WP_001291435.1 NZ_CP123237:3509233-3509451 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278715 WP_000344800.1 NZ_CP123237:3508833-3509207 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References