Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2467861..2468499 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag QET42_RS12215 Protein ID WP_001447010.1
Coordinates 2468323..2468499 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QET42_RS12210 Protein ID WP_001270286.1
Coordinates 2467861..2468277 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS12190 (2463013) 2463013..2463954 - 942 WP_001251304.1 ABC transporter permease -
QET42_RS12195 (2463955) 2463955..2464968 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QET42_RS12200 (2464986) 2464986..2466131 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QET42_RS12205 (2466376) 2466376..2467782 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QET42_RS12210 (2467861) 2467861..2468277 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QET42_RS12215 (2468323) 2468323..2468499 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QET42_RS12220 (2468721) 2468721..2468951 + 231 WP_000494244.1 YncJ family protein -
QET42_RS12225 (2469043) 2469043..2471004 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QET42_RS12230 (2471077) 2471077..2471613 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QET42_RS12235 (2471705) 2471705..2472880 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T278714 WP_001447010.1 NZ_CP123237:c2468499-2468323 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278714 WP_001270286.1 NZ_CP123237:c2468277-2467861 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References