Detailed information of TA system TA027870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 4137529..4138093
• Replicon: chromosome
• Accession: NC_017955
• Organism: Modestobacter marinus

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: I4F1P1
• Locus tag: MODMU_RS19625
• Protein ID: WP_014742123.1
• Coordinates: 4137529..4137876 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: I4F1P2
• Locus tag: MODMU_RS19630
• Protein ID: WP_014742124.1
• Coordinates: 4137863..4138093 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MODMU_RS19610	4133123..4134739	-	1617	WP_014742119.1	ABC transporter ATP-binding protein	-
MODMU_RS19615	4134736..4135851	-	1116	WP_014742120.1	BMP family protein	-
MODMU_RS19620	4135981..4137519	+	1539	WP_014742122.1	PucR family transcriptional regulator	-
MODMU_RS19625	4137529..4137876	-	348	WP_014742123.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MODMU_RS19630	4137863..4138093	-	231	WP_014742124.1	ribbon-helix-helix domain-containing protein	Antitoxin
MODMU_RS19635	4138215..4138649	+	435	WP_014742125.1	hypothetical protein	-
MODMU_RS19640	4138852..4139826	+	975	WP_014742126.1	ABC transporter substrate-binding protein	-
MODMU_RS19645	4139885..4140751	+	867	WP_014742127.1	ABC transporter permease	-
MODMU_RS19650	4140762..4141547	+	786	WP_014742128.1	ABC transporter ATP-binding protein	-
MODMU_RS19655	4141544..4141912	+	369	WP_051144040.1	hypothetical protein	-
MODMU_RS19660	4142050..4142502	+	453	WP_014742130.1	hypothetical protein	-
MODMU_RS19665	4142687..4142974	+	288	WP_014742131.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12353.20 Da
• Isoelectric Point: 11.1582

>T27870 WP_014742123.1 NC_017955:c4137876-4137529 [Modestobacter marinus]
MRRGEVRLVDLEPVRGSEASKRRPAVLVSNDRANATAARLGRGVVTVVPVTSNVSRVFAFQTLLPADRTGLTADSKAQAE
QVRAVAVERVGAVLGQVPVDLMSELDEALRVHLQL

Nucleotide

• Length: 348 bp

>T27870 NC_017955:c4137876-4137529 [Modestobacter marinus]
ATGCGCCGCGGTGAGGTCCGGCTCGTCGACCTGGAGCCCGTCCGGGGCAGCGAGGCGAGCAAGCGGCGGCCGGCCGTGCT
GGTGAGCAACGACCGCGCCAACGCCACGGCCGCGAGGCTGGGGCGCGGCGTGGTGACGGTCGTGCCGGTGACCAGCAACG
TGTCACGGGTGTTCGCCTTTCAGACACTGCTCCCGGCAGACCGGACAGGGCTGACCGCCGACTCCAAGGCCCAGGCGGAG
CAGGTTCGGGCGGTGGCCGTCGAGCGGGTCGGTGCTGTGCTGGGCCAGGTGCCCGTGGACCTGATGAGCGAGTTGGACGA
GGCGCTGCGGGTCCATCTACAGCTCTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8429.29 Da
• Isoelectric Point: 4.0808

>AT27870 WP_014742124.1 NC_017955:c4138093-4137863 [Modestobacter marinus]
MKLSVSLPDDDVALLDEYARTAGLRGRSAVIQHALRLLRQVELEQDYAAAWEEWEASGEQSTWDTTAGDGLIDAPR

Nucleotide

• Length: 231 bp

>AT27870 NC_017955:c4138093-4137863 [Modestobacter marinus]
ATGAAGCTGAGCGTCAGCTTGCCCGACGACGATGTGGCCCTCCTCGACGAGTACGCCCGCACCGCCGGTCTGCGGGGGCG
GTCCGCGGTGATCCAGCACGCGCTGCGACTGCTCCGCCAGGTCGAGCTCGAGCAGGACTACGCCGCGGCGTGGGAGGAAT
GGGAAGCCTCCGGCGAGCAGTCGACATGGGACACCACCGCGGGAGACGGCCTGATCGATGCGCCGCGGTGA

Structures

Toxin

• AlphaFold DB: I4F1P1

Antitoxin

• AlphaFold DB: I4F1P2