Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4434111..4434608 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QET41_RS21685 Protein ID WP_001173343.1
Coordinates 4434111..4434284 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QET41_RS21690 Protein ID WP_001312331.1
Coordinates 4434312..4434608 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS21675 (4430781) 4430781..4432238 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QET41_RS21680 (4432475) 4432475..4433992 + 1518 WP_000003806.1 lysine--tRNA ligase -
QET41_RS21685 (4434111) 4434111..4434284 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QET41_RS21690 (4434312) 4434312..4434608 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QET41_RS21695 (4434837) 4434837..4435109 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QET41_RS21700 (4435121) 4435121..4435351 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QET41_RS21705 (4435532) 4435532..4437163 + 1632 WP_001216482.1 sensor histidine kinase -
QET41_RS21710 (4437160) 4437160..4437879 + 720 WP_001540474.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4378473..4434608 56135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278692 WP_001173343.1 NZ_CP123231:c4434284-4434111 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT278692 WP_001312331.1 NZ_CP123231:c4434608-4434312 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References