Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4163567..4164381 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QET41_RS20300 Protein ID WP_001054376.1
Coordinates 4163567..4163824 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag QET41_RS20305 Protein ID WP_001540600.1
Coordinates 4163836..4164381 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS20275 (4158855) 4158855..4159961 + 1107 WP_001774143.1 N-acetylneuraminate epimerase -
QET41_RS20280 (4160026) 4160026..4161006 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QET41_RS20285 (4161116) 4161116..4161321 + 206 Protein_3971 HNH endonuclease -
QET41_RS20290 (4161589) 4161589..4162829 - 1241 Protein_3972 helicase YjhR -
QET41_RS20295 (4162945) 4162945..4163076 + 132 WP_001309182.1 hypothetical protein -
QET41_RS20300 (4163567) 4163567..4163824 + 258 WP_001054376.1 YjhX family toxin Toxin
QET41_RS20305 (4163836) 4163836..4164381 + 546 WP_001540600.1 N-acetyltransferase Antitoxin
QET41_RS20310 (4164437) 4164437..4165183 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QET41_RS20315 (4165352) 4165352..4165570 + 219 Protein_3977 hypothetical protein -
QET41_RS20320 (4165608) 4165608..4165724 + 117 Protein_3978 VOC family protein -
QET41_RS20325 (4165969) 4165969..4167090 + 1122 WP_000010829.1 M42 family metallopeptidase -
QET41_RS20330 (4167087) 4167087..4167365 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QET41_RS20335 (4167377) 4167377..4168690 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4153353..4172605 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T278690 WP_001054376.1 NZ_CP123231:4163567-4163824 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT278690 WP_001540600.1 NZ_CP123231:4163836-4164381 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References