Detailed information of TA system TA027869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2502380..2502927
• Replicon: chromosome
• Accession: NC_017955
• Organism: Modestobacter marinus

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I4EX45
• Locus tag: MODMU_RS12165
• Protein ID: WP_014740550.1
• Coordinates: 2502380..2502655 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MODMU_RS12170
• Protein ID: WP_041795217.1
• Coordinates: 2502652..2502927 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MODMU_RS12150	2498260..2499174	+	915	WP_197537406.1	alpha/beta hydrolase	-
MODMU_RS12155	2499330..2500184	-	855	WP_014740548.1	methyltransferase domain-containing protein	-
MODMU_RS12160	2500249..2501961	-	1713	WP_014740549.1	helix-turn-helix transcriptional regulator	-
MODMU_RS12165	2502380..2502655	-	276	WP_014740550.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MODMU_RS12170	2502652..2502927	-	276	WP_041795217.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MODMU_RS12175	2502872..2503423	-	552	WP_014740552.1	hypothetical protein	-
MODMU_RS12180	2503948..2504790	+	843	WP_014740553.1	MEDS domain-containing protein	-
MODMU_RS12185	2504787..2505725	+	939	WP_014740554.1	sensor histidine kinase	-
MODMU_RS12195	2506573..2507082	+	510	WP_014740556.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2487233..2530719	43486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (38-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10063.55 Da
• Isoelectric Point: 9.7419

>T27869 WP_014740550.1 NC_017955:c2502655-2502380 [Modestobacter marinus]
VTGPTAHTVVLSAAAKRAIERDLPEPVAVAVVNFLYGALAADPYRVGKPLRFDLEGYWSARRGQYRVVYSIHADEVLVRV
VRISHRADVYG

Nucleotide

• Length: 276 bp

>T27869 NC_017955:c2502655-2502380 [Modestobacter marinus]
GTGACCGGTCCGACGGCTCACACCGTCGTCCTCTCCGCCGCGGCCAAGCGGGCCATCGAGCGCGACCTCCCCGAGCCGGT
CGCAGTCGCGGTCGTCAACTTCTTGTACGGCGCACTCGCCGCGGACCCGTACCGCGTCGGCAAGCCTCTGCGTTTCGACC
TGGAGGGCTACTGGTCCGCACGGAGGGGTCAGTACCGCGTCGTCTACTCGATCCACGCCGACGAGGTCCTCGTCCGCGTC
GTGCGCATCTCGCACCGCGCCGACGTCTACGGCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9891.10 Da
• Isoelectric Point: 5.1053

>AT27869 WP_041795217.1 NC_017955:c2502927-2502652 [Modestobacter marinus]
MTTQSLATVKARFSQVIDEVAGTHDRVTITRNGSPVAVILAVGDYESLMETLEVLSDPQARSEIRRAEAEMAAGNSYDEA
QVRAALAARRR

Nucleotide

• Length: 276 bp

>AT27869 NC_017955:c2502927-2502652 [Modestobacter marinus]
ATGACGACGCAGTCGCTCGCGACGGTGAAGGCTCGGTTCAGCCAGGTGATCGATGAGGTGGCCGGCACCCACGACCGGGT
CACGATCACGCGCAACGGCAGTCCGGTGGCCGTCATCCTCGCGGTCGGGGACTACGAGTCGTTGATGGAGACCCTTGAGG
TCCTGTCCGACCCTCAGGCCCGCTCGGAGATCCGGCGAGCCGAGGCCGAGATGGCGGCCGGGAACTCCTATGACGAGGCC
CAGGTGCGGGCGGCACTGGCGGCTCGCCGCCGGTGA

Structures

Toxin

• AlphaFold DB: I4EX45