278682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3535266..3535884 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QET41_RS17305 Protein ID WP_001291435.1
Coordinates 3535666..3535884 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QET41_RS17300 Protein ID WP_000344800.1
Coordinates 3535266..3535640 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS17290 (3530355) 3530355..3531548 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QET41_RS17295 (3531571) 3531571..3534720 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QET41_RS17300 (3535266) 3535266..3535640 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QET41_RS17305 (3535666) 3535666..3535884 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QET41_RS17310 (3536057) 3536057..3536608 + 552 WP_000102539.1 maltose O-acetyltransferase -
QET41_RS17315 (3536724) 3536724..3537194 + 471 WP_000136192.1 YlaC family protein -
QET41_RS17320 (3537358) 3537358..3538908 + 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QET41_RS17325 (3538950) 3538950..3539303 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QET41_RS17335 (3539682) 3539682..3539993 + 312 WP_000409908.1 MGMT family protein -
QET41_RS17340 (3540024) 3540024..3540596 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278682 WP_001291435.1 NZ_CP123231:3535666-3535884 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278682 WP_000344800.1 NZ_CP123231:3535266-3535640 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References