Detailed information of TA system TA027868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-VapB
• Location: 1559794..1560356
• Replicon: chromosome
• Accession: NC_017955
• Organism: Modestobacter marinus

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: I4EUF6
• Locus tag: MODMU_RS07590
• Protein ID: WP_014739621.1
• Coordinates: 1559794..1560123 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: I4EUF7
• Locus tag: MODMU_RS07595
• Protein ID: WP_014739622.1
• Coordinates: 1560120..1560356 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MODMU_RS07570	1555049..1555912	-	864	WP_014739617.1	SDR family oxidoreductase	-
MODMU_RS07575	1555990..1558539	+	2550	WP_014739618.1	LuxR family transcriptional regulator	-
MODMU_RS07580	1558606..1559058	+	453	WP_014739619.1	cupin domain-containing protein	-
MODMU_RS07585	1559145..1559639	+	495	WP_051144148.1	GNAT family N-acetyltransferase	-
MODMU_RS07590	1559794..1560123	-	330	WP_014739621.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MODMU_RS07595	1560120..1560356	-	237	WP_014739622.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MODMU_RS07600	1560727..1561059	-	333	WP_166503423.1	hypothetical protein	-
MODMU_RS07605	1561995..1562228	+	234	WP_014739625.1	hypothetical protein	-
MODMU_RS07610	1562218..1562529	+	312	WP_014739626.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MODMU_RS07615	1562803..1563414	-	612	WP_041795060.1	dihydrofolate reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (9-48)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11904.91 Da
• Isoelectric Point: 6.8837

>T27868 WP_014739621.1 NC_017955:c1560123-1559794 [Modestobacter marinus]
VTTLPARGEVWWCEMAEIGRRPVVVLSRDTVIPRHRRALVAPCTTTIRGLVSEVGLEPGEDPVPRRCVVNMDSVESVSVA
ILVERLGRLADTRMRQICGALAVAVDCAE

Nucleotide

• Length: 330 bp

>T27868 NC_017955:c1560123-1559794 [Modestobacter marinus]
GTGACGACGCTTCCCGCACGCGGTGAGGTCTGGTGGTGCGAGATGGCCGAGATCGGGCGCCGCCCGGTCGTCGTCCTCTC
CCGCGACACAGTGATCCCCCGGCACCGGCGCGCACTCGTCGCACCATGCACCACCACGATCCGCGGCCTGGTCAGCGAAG
TCGGCCTCGAGCCCGGCGAGGACCCGGTACCCCGCCGCTGCGTGGTCAACATGGACTCGGTCGAGAGCGTCTCTGTCGCG
ATCCTCGTTGAGCGGCTCGGACGATTGGCCGACACCCGCATGCGCCAGATCTGCGGAGCCCTCGCCGTCGCGGTCGACTG
CGCGGAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8635.39 Da
• Isoelectric Point: 4.3712

>AT27868 WP_014739622.1 NC_017955:c1560356-1560120 [Modestobacter marinus]
MSRTRLSTTVDDDLLQAARRLRSGDTDAAMIDEALRALVARHRSAEVDASYAAYDEHPLDEPDEWGDLASFREAAGRS

Nucleotide

• Length: 237 bp

>AT27868 NC_017955:c1560356-1560120 [Modestobacter marinus]
ATGAGTAGAACACGGCTCAGCACCACCGTCGACGACGATCTCCTCCAGGCCGCTCGACGGTTGAGATCCGGTGACACCGA
CGCCGCCATGATCGATGAGGCGCTGCGCGCGCTGGTGGCGCGCCACCGTTCGGCCGAAGTCGATGCGAGCTACGCCGCCT
ACGACGAGCACCCCCTCGACGAACCGGACGAGTGGGGTGACTTGGCGTCGTTCCGCGAAGCCGCCGGACGGTCGTGA

Structures

Toxin

• AlphaFold DB: I4EUF6

Antitoxin

• AlphaFold DB: I4EUF7