Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1130265..1130848 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name mazF Uniprot ID S1PVD8
Locus tag QET41_RS05400 Protein ID WP_000254749.1
Coordinates 1130513..1130848 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag QET41_RS05395 Protein ID WP_000581937.1
Coordinates 1130265..1130513 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS05385 (1126604) 1126604..1127905 + 1302 WP_000046817.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
QET41_RS05390 (1127953) 1127953..1130187 + 2235 WP_000226797.1 GTP diphosphokinase -
QET41_RS05395 (1130265) 1130265..1130513 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QET41_RS05400 (1130513) 1130513..1130848 + 336 WP_000254749.1 endoribonuclease MazF Toxin
QET41_RS05405 (1130920) 1130920..1131711 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
QET41_RS05410 (1131939) 1131939..1133576 + 1638 WP_001774030.1 CTP synthase (glutamine hydrolyzing) -
QET41_RS05415 (1133664) 1133664..1134962 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12137.06 Da        Isoelectric Point: 8.7218

>T278674 WP_000254749.1 NZ_CP123231:1130513-1130848 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT278674 WP_000581937.1 NZ_CP123231:1130265-1130513 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PVD8

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References