Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 974267..974921 Replicon chromosome
Accession NZ_CP123231
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QET41_RS04770 Protein ID WP_000244781.1
Coordinates 974514..974921 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QET41_RS04765 Protein ID WP_000354046.1
Coordinates 974267..974533 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS04745 (970355) 970355..971788 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
QET41_RS04750 (971833) 971833..972144 + 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
QET41_RS04755 (972308) 972308..972967 + 660 WP_000250274.1 hemolysin III family protein -
QET41_RS04760 (973044) 973044..974024 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QET41_RS04765 (974267) 974267..974533 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QET41_RS04770 (974514) 974514..974921 + 408 WP_000244781.1 protein YgfX Toxin
QET41_RS04775 (974961) 974961..975482 - 522 WP_001055874.1 flavodoxin FldB -
QET41_RS04780 (975594) 975594..976490 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QET41_RS04785 (976515) 976515..977225 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QET41_RS04790 (977231) 977231..978964 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T278673 WP_000244781.1 NZ_CP123231:974514-974921 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278673 WP_000354046.1 NZ_CP123231:974267-974533 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References