Detailed information of TA system TA027867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-TIGR02293
• Location: 809572..810476
• Replicon: chromosome
• Accession: NC_017955
• Organism: Modestobacter marinus

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: I4ESA3
• Locus tag: MODMU_RS03920
• Protein ID: WP_014738874.1
• Coordinates: 809913..810476 (+)
• Length: 188 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: I4ESA2
• Locus tag: MODMU_RS03915
• Protein ID: WP_014738873.1
• Coordinates: 809572..809916 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MODMU_RS03895	806359..806568	+	210	WP_014738869.1	helix-turn-helix domain-containing protein	-
MODMU_RS03900	806755..807411	+	657	WP_014738870.1	hypothetical protein	-
MODMU_RS03905	807404..808093	+	690	WP_041794932.1	hypothetical protein	-
MODMU_RS29015	808334..809494	-	1161	WP_014738872.1	hypothetical protein	-
MODMU_RS03915	809572..809916	+	345	WP_014738873.1	DUF2384 domain-containing protein	Antitoxin
MODMU_RS03920	809913..810476	+	564	WP_014738874.1	RES domain-containing protein	Toxin
MODMU_RS03925	810641..810823	+	183	WP_014738875.1	hypothetical protein	-
MODMU_RS03930	810896..812083	+	1188	WP_014738876.1	hypothetical protein	-
MODMU_RS03935	812109..813209	+	1101	WP_014738877.1	mandelate racemase/muconate lactonizing enzyme family protein	-
MODMU_RS03940	813206..814087	+	882	WP_041795893.1	NAD(P)-dependent oxidoreductase	-
MODMU_RS03945	814084..814821	+	738	WP_014738879.1	DUF2510 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (27-173)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (70-111)

Sequences

Toxin

Protein

• Length: 188 a.a.
• Molecular weight: 20377.96 Da
• Isoelectric Point: 4.5985

>T27867 WP_014738874.1 NC_017955:809913-810476 [Modestobacter marinus]
VSVPLDEDVVQQVNDAGSTPWSGTVHRYTAAEYEPLSGEGAYKFGGRWNPRRIFPTIYLARPLSASMGELRRLAEATSVD
PQALLRRGYVLHDIEVVDLPVLDLRTPAALAFVGLSVDDIADDDWAACQSVGHAAWFLEYAGVLAPSATGDGHVLAAFEH
RIQPGQMAVLESRPLDLETYLRHCPPA

Nucleotide

• Length: 564 bp

>T27867 NC_017955:809913-810476 [Modestobacter marinus]
GTGAGCGTCCCGTTGGATGAGGACGTCGTTCAGCAGGTTAACGACGCCGGGTCCACGCCGTGGTCGGGAACCGTCCACCG
TTACACGGCCGCCGAGTACGAACCTCTCTCCGGAGAGGGCGCCTACAAGTTCGGCGGTCGCTGGAACCCGCGGCGCATCT
TCCCGACGATCTACCTGGCCCGGCCGCTGAGCGCCTCGATGGGCGAGCTGCGCCGCCTGGCTGAAGCAACCTCGGTCGAT
CCGCAAGCACTTCTACGTCGGGGATACGTCCTGCACGACATCGAGGTGGTCGACCTTCCGGTGCTAGACCTACGCACCCC
GGCCGCCCTTGCCTTCGTCGGACTCAGCGTCGATGACATCGCCGATGACGATTGGGCTGCGTGCCAGTCAGTAGGCCATG
CGGCCTGGTTTCTCGAATACGCCGGCGTTCTGGCTCCGTCCGCCACCGGGGACGGCCACGTCCTCGCGGCGTTCGAGCAC
CGAATCCAGCCGGGACAGATGGCCGTCCTCGAGTCCCGACCGCTGGATCTGGAGACGTACCTGAGGCACTGCCCGCCTGC
CTAG

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12181.92 Da
• Isoelectric Point: 5.5385

>AT27867 WP_014738873.1 NC_017955:809572-809916 [Modestobacter marinus]
MATQGALAHKVAGLISGLGLTQEEIGTIVDASARSVSRWSSGEVVPQRLNKQRLVELAYVAEAVTAVLPPDEANLWMFAP
NRMLGHESPAARIHDGHYRDVLDLIEAIASGVVV

Nucleotide

• Length: 345 bp

>AT27867 NC_017955:809572-809916 [Modestobacter marinus]
ATGGCGACACAGGGAGCCCTCGCGCACAAAGTAGCCGGCCTGATCTCCGGCCTCGGGCTCACGCAAGAAGAGATCGGAAC
GATCGTCGACGCCTCCGCGCGGTCGGTCTCGCGCTGGTCCAGCGGCGAGGTCGTGCCTCAGCGGCTGAACAAGCAGCGTC
TGGTGGAACTCGCCTATGTTGCCGAAGCGGTCACCGCGGTGCTGCCCCCGGATGAAGCCAATCTGTGGATGTTCGCCCCC
AATCGCATGCTGGGACACGAGTCCCCCGCCGCGCGCATCCACGACGGGCACTACCGGGACGTCCTGGACCTGATCGAGGC
GATTGCTAGCGGCGTGGTGGTGTGA

Structures

Toxin

• AlphaFold DB: I4ESA3

Antitoxin

• AlphaFold DB: I4ESA2