Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 9719..10293 Replicon plasmid pPae2250Z
Accession NZ_CP123226
Organism Pseudomonas amygdali pv. aesculi strain 2250

Toxin (Protein)


Gene name vapC Uniprot ID Q48BC5
Locus tag QEP70_RS29220 Protein ID WP_003344395.1
Coordinates 9916..10293 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QEP70_RS29215 Protein ID WP_060406773.1
Coordinates 9719..9919 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP70_RS29195 5512..5721 - 210 Protein_5 hypothetical protein -
QEP70_RS29200 5792..6220 - 429 WP_060409866.1 GntR family transcriptional regulator -
QEP70_RS29205 6266..8554 - 2289 WP_280124526.1 F-type conjugative transfer protein TrbC -
QEP70_RS29210 8541..9626 - 1086 WP_060409950.1 thioredoxin fold domain-containing protein -
QEP70_RS29215 9719..9919 + 201 WP_060406773.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEP70_RS29220 9916..10293 + 378 WP_003344395.1 PIN domain-containing protein Toxin
QEP70_RS29225 10283..11485 - 1203 WP_060409842.1 hypothetical protein -
QEP70_RS29230 11577..12227 - 651 WP_060409909.1 plasmid IncI1-type surface exclusion protein ExcA -
QEP70_RS29235 12224..12469 - 246 WP_003344389.1 hypothetical protein -
QEP70_RS29240 12572..14716 - 2145 WP_060409910.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73292 73292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13633.73 Da        Isoelectric Point: 6.4723

>T278664 WP_003344395.1 NZ_CP123226:9916-10293 [Pseudomonas amygdali pv. aesculi]
VKGVLVDTSVWVEHFRNNSPELVNLLSQDRVLIHPMVIGELACGTPPDRSNTLTDLGDLRGAQQPTVSEVIAFLNTHKLY
GLGCGLVDMTLLASALLSGTALWTLDKRLERLASRMAVSYQPPTH

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7443.69 Da        Isoelectric Point: 8.7091

>AT278664 WP_060406773.1 NZ_CP123226:9719-9919 [Pseudomonas amygdali pv. aesculi]
MRTTVTIDDALYRRALEVADPAMDKADLFREAVQTFVRIQAAKRLMALGATLPAMEDIARRHEKAL

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3GPE2

Antitoxin

Source ID Structure

References