Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 68110..68684 Replicon plasmid pPae2203Z
Accession NZ_CP123217
Organism Pseudomonas amygdali pv. aesculi strain 2203

Toxin (Protein)


Gene name vapC Uniprot ID Q48BC5
Locus tag QEP68_RS29160 Protein ID WP_003344395.1
Coordinates 68110..68487 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QEP68_RS29165 Protein ID WP_060406773.1
Coordinates 68484..68684 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP68_RS29140 63687..65831 + 2145 WP_060409910.1 DotA/TraY family protein -
QEP68_RS29145 65934..66179 + 246 WP_003344389.1 hypothetical protein -
QEP68_RS29150 66176..66826 + 651 WP_060409909.1 plasmid IncI1-type surface exclusion protein ExcA -
QEP68_RS29155 66918..68120 + 1203 WP_060409842.1 hypothetical protein -
QEP68_RS29160 68110..68487 - 378 WP_003344395.1 PIN domain-containing protein Toxin
QEP68_RS29165 68484..68684 - 201 WP_060406773.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEP68_RS29170 68777..69862 + 1086 WP_060409950.1 thioredoxin fold domain-containing protein -
QEP68_RS29175 69849..72137 + 2289 WP_243580938.1 F-type conjugative transfer protein TrbC -
QEP68_RS29180 72183..72611 + 429 WP_060409866.1 GntR family transcriptional regulator -
QEP68_RS29185 72682..72891 + 210 Protein_85 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73292 73292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13633.73 Da        Isoelectric Point: 6.4723

>T278656 WP_003344395.1 NZ_CP123217:c68487-68110 [Pseudomonas amygdali pv. aesculi]
VKGVLVDTSVWVEHFRNNSPELVNLLSQDRVLIHPMVIGELACGTPPDRSNTLTDLGDLRGAQQPTVSEVIAFLNTHKLY
GLGCGLVDMTLLASALLSGTALWTLDKRLERLASRMAVSYQPPTH

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7443.69 Da        Isoelectric Point: 8.7091

>AT278656 WP_060406773.1 NZ_CP123217:c68684-68484 [Pseudomonas amygdali pv. aesculi]
MRTTVTIDDALYRRALEVADPAMDKADLFREAVQTFVRIQAAKRLMALGATLPAMEDIARRHEKAL

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3GPE2

Antitoxin

Source ID Structure

References