278654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE-Phd
Location 111284..111895 Replicon plasmid pCOR2203
Accession NZ_CP123216
Organism Pseudomonas amygdali pv. aesculi strain 2203

Toxin (Protein)


Gene name PfiT Uniprot ID A0A0P9HD56
Locus tag QEP68_RS28415 Protein ID WP_005734903.1
Coordinates 111284..111634 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0P9H624
Locus tag QEP68_RS28420 Protein ID WP_005734904.1
Coordinates 111647..111895 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP68_RS28380 106613..107422 + 810 WP_243580873.1 IS21-like element ISPsy4 family helper ATPase IstB -
QEP68_RS28385 107465..107572 + 108 Protein_121 type II toxin-antitoxin system RelE/ParE family toxin -
QEP68_RS28390 107712..107987 + 276 WP_236732658.1 hypothetical protein -
QEP68_RS28395 108114..109091 - 978 WP_032701292.1 IS5 family transposase -
QEP68_RS28400 109363..110343 + 981 WP_243580935.1 IS5-like element ISPsy2 family transposase -
QEP68_RS28405 110538..110765 + 228 WP_057412924.1 polymorphic toxin type 33 domain-containing protein -
QEP68_RS28410 110774..111178 + 405 WP_005734902.1 DUF4279 domain-containing protein -
QEP68_RS28415 111284..111634 - 351 WP_005734903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEP68_RS28420 111647..111895 - 249 WP_005734904.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QEP68_RS28425 112226..113188 + 963 WP_005734905.1 tyrosine-type recombinase/integrase -
QEP68_RS28430 113264..113578 - 315 WP_005734906.1 hypothetical protein -
QEP68_RS28440 115119..115823 + 705 WP_060409903.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..181117 181117
- inside IScluster/Tn - - 100517..126978 26461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13014.96 Da        Isoelectric Point: 4.2805

>T278654 WP_005734903.1 NZ_CP123216:c111634-111284 [Pseudomonas amygdali pv. aesculi]
MNTFALRFTEVAQQSIEDQVEHLAITQGFSLAAQRINTLIDVIQDKLLSTPLGYPVSPQLSELGILHYRELNTDGYRIFY
EVMDSDGITDIAVLLVLGGKQSVEQALIRYCLLQPM

Download         Length: 351 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9338.68 Da        Isoelectric Point: 9.8450

>AT278654 WP_005734904.1 NZ_CP123216:c111895-111647 [Pseudomonas amygdali pv. aesculi]
MRVETISYLKRNAADLPLDEPLVVTQNGVPAYVVESYADRKRRDESIALVKLLAISSRDYSQGKHCSTDELKARLSRRFA
QK

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9HD56

Antitoxin

Source ID Structure
AlphaFold DB A0A0P9H624

References