Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1378697..1379180 Replicon chromosome
Accession NC_017950
Organism Streptococcus suis ST1

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag SSUST1_RS06845 Protein ID WP_009910443.1
Coordinates 1378697..1378957 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUST1_RS06850 Protein ID WP_012775256.1
Coordinates 1378959..1379180 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST1_RS06820 1374082..1375311 - 1230 WP_014736149.1 tetratricopeptide repeat protein -
SSUST1_RS06825 1375301..1376467 - 1167 WP_002935690.1 AI-2E family transporter -
SSUST1_RS06830 1376603..1377607 + 1005 WP_014736150.1 lactonase family protein -
SSUST1_RS06835 1377671..1377856 + 186 WP_002935693.1 hypothetical protein -
SSUST1_RS06840 1377889..1378530 - 642 WP_002935700.1 HAD family hydrolase -
SSUST1_RS06845 1378697..1378957 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUST1_RS06850 1378959..1379180 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUST1_RS06855 1379404..1380711 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUST1_RS06860 1380861..1381313 + 453 WP_024405234.1 DUF1694 domain-containing protein -
SSUST1_RS06870 1381540..1382668 - 1129 Protein_1300 glycerate kinase -
SSUST1_RS06875 1382776..1383426 + 651 WP_014736153.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T27865 WP_009910443.1 NC_017950:c1378957-1378697 [Streptococcus suis ST1]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27865 NC_017950:c1378957-1378697 [Streptococcus suis ST1]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27865 WP_012775256.1 NC_017950:c1379180-1378959 [Streptococcus suis ST1]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27865 NC_017950:c1379180-1378959 [Streptococcus suis ST1]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References