Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 99610..100184 Replicon plasmid pPae1804ZI
Accession NZ_CP123213
Organism Pseudomonas amygdali pv. aesculi strain 1804

Toxin (Protein)


Gene name vapC Uniprot ID Q48BC5
Locus tag QEP69_RS29245 Protein ID WP_003344395.1
Coordinates 99610..99987 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QEP69_RS29250 Protein ID WP_060406773.1
Coordinates 99984..100184 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP69_RS29225 95187..97331 + 2145 WP_060409910.1 DotA/TraY family protein -
QEP69_RS29230 97434..97679 + 246 WP_003344389.1 hypothetical protein -
QEP69_RS29235 97676..98326 + 651 WP_060409909.1 plasmid IncI1-type surface exclusion protein ExcA -
QEP69_RS29240 98418..99620 + 1203 WP_060409842.1 hypothetical protein -
QEP69_RS29245 99610..99987 - 378 WP_003344395.1 PIN domain-containing protein Toxin
QEP69_RS29250 99984..100184 - 201 WP_060406773.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEP69_RS29255 100277..101362 + 1086 WP_060409950.1 thioredoxin fold domain-containing protein -
QEP69_RS29260 101349..103637 + 2289 WP_280124526.1 F-type conjugative transfer protein TrbC -
QEP69_RS29265 103683..104111 + 429 WP_060409866.1 GntR family transcriptional regulator -
QEP69_RS29270 104182..104391 + 210 Protein_128 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..136841 136841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13633.73 Da        Isoelectric Point: 6.4723

>T278647 WP_003344395.1 NZ_CP123213:c99987-99610 [Pseudomonas amygdali pv. aesculi]
VKGVLVDTSVWVEHFRNNSPELVNLLSQDRVLIHPMVIGELACGTPPDRSNTLTDLGDLRGAQQPTVSEVIAFLNTHKLY
GLGCGLVDMTLLASALLSGTALWTLDKRLERLASRMAVSYQPPTH

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7443.69 Da        Isoelectric Point: 8.7091

>AT278647 WP_060406773.1 NZ_CP123213:c100184-99984 [Pseudomonas amygdali pv. aesculi]
MRTTVTIDDALYRRALEVADPAMDKADLFREAVQTFVRIQAAKRLMALGATLPAMEDIARRHEKAL

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3GPE2

Antitoxin

Source ID Structure

References