Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 964295..964790 Replicon chromosome
Accession NC_017950
Organism Streptococcus suis ST1

Toxin (Protein)


Gene name relE Uniprot ID A0A4V0E2N5
Locus tag SSUST1_RS04800 Protein ID WP_014735845.1
Coordinates 964524..964790 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V0E2R6
Locus tag SSUST1_RS04795 Protein ID WP_014735844.1
Coordinates 964295..964534 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST1_RS04775 959303..959677 + 375 WP_029694721.1 NisI/SpaI family lantibiotic immunity lipoprotein -
SSUST1_RS04780 959686..960438 + 753 WP_014735841.1 ABC transporter ATP-binding protein -
SSUST1_RS04785 960439..962385 + 1947 WP_014735842.1 FtsX-like permease family protein -
SSUST1_RS04790 962767..963969 - 1203 WP_041179326.1 IS110 family transposase -
SSUST1_RS04795 964295..964534 + 240 WP_014735844.1 hypothetical protein Antitoxin
SSUST1_RS04800 964524..964790 + 267 WP_014735845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUST1_RS04805 964832..965497 + 666 WP_024405277.1 response regulator transcription factor -
SSUST1_RS04810 965494..966435 + 942 WP_014735847.1 sensor histidine kinase -
SSUST1_RS04815 966510..968018 + 1509 WP_014735848.1 phosphoglucomutase -
SSUST1_RS04820 968081..969151 - 1071 WP_014735849.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 962767..964005 1238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.02 Da        Isoelectric Point: 10.3331

>T27864 WP_014735845.1 NC_017950:964524-964790 [Streptococcus suis ST1]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDDCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T27864 NC_017950:964524-964790 [Streptococcus suis ST1]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACTGCGGCAAGTTTGATTTT
GCGCTATCTTTACAAGCATATTGACGATTGCGACAACCCCAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAACTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8909.12 Da        Isoelectric Point: 3.7832

>AT27864 WP_014735844.1 NC_017950:964295-964534 [Streptococcus suis ST1]
MTAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT27864 NC_017950:964295-964534 [Streptococcus suis ST1]
ATGACAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTACGATGCGCGTGTGGCAGACATAGCTTGGGCAG
AATACCAAGAAGACTTAGCGAATGGAATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0E2N5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0E2R6

References