Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 3391..3992 Replicon plasmid unnamed3
Accession NZ_CP123199
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag PAE60_RS25110 Protein ID WP_001216030.1
Coordinates 3612..3992 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PAE60_RS25105 Protein ID WP_001190712.1
Coordinates 3391..3612 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS25095 (PAE60_025095) 375..1655 - 1281 WP_260240996.1 restriction endonuclease subunit S -
PAE60_RS25100 (PAE60_025100) 1652..3208 - 1557 WP_029401414.1 type I restriction-modification system subunit M -
PAE60_RS25105 (PAE60_025105) 3391..3612 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAE60_RS25110 (PAE60_025110) 3612..3992 + 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PAE60_RS25115 (PAE60_025115) 3997..4176 + 180 WP_000113018.1 hypothetical protein -
PAE60_RS25120 (PAE60_025120) 4204..5247 + 1044 WP_000648833.1 DUF968 domain-containing protein -
PAE60_RS25125 (PAE60_025125) 5336..5788 + 453 WP_032305380.1 hypothetical protein -
PAE60_RS25130 (PAE60_025130) 5875..7068 + 1194 WP_000219604.1 terminase -
PAE60_RS25135 (PAE60_025135) 7068..8552 + 1485 WP_000124150.1 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..96709 96709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T278634 WP_001216030.1 NZ_CP123199:3612-3992 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT278634 WP_001190712.1 NZ_CP123199:3391-3612 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References