Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4602430..4603016 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PAE60_RS23435 Protein ID WP_042014162.1
Coordinates 4602430..4602660 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PAE60_RS23440 Protein ID WP_000593555.1
Coordinates 4602657..4603016 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS23425 (4598467) 4598467..4601202 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PAE60_RS23430 (4601202) 4601202..4602326 + 1125 WP_001314210.1 ABC transporter permease -
PAE60_RS23435 (4602430) 4602430..4602660 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PAE60_RS23440 (4602657) 4602657..4603016 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PAE60_RS23445 (4603136) 4603136..4603537 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PAE60_RS23450 (4603543) 4603543..4604349 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PAE60_RS23455 (4604346) 4604346..4605110 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PAE60_RS23460 (4605110) 4605110..4605943 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PAE60_RS23465 (4605940) 4605940..4606884 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T278632 WP_042014162.1 NZ_CP123197:4602430-4602660 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT278632 WP_000593555.1 NZ_CP123197:4602657-4603016 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References