Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3910198..3911242 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag PAE60_RS20245 Protein ID WP_000019186.1
Coordinates 3910198..3910746 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag PAE60_RS20250 Protein ID WP_000287252.1
Coordinates 3910769..3911242 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS20210 (3905410) 3905410..3905961 - 552 WP_000515860.1 protein YmfL -
PAE60_RS20215 (3906005) 3906005..3906205 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
PAE60_RS20220 (3906296) 3906296..3906970 + 675 WP_000859462.1 LexA family transcriptional repressor -
PAE60_RS20225 (3907637) 3907637..3907999 + 363 WP_000135682.1 protein YfdP -
PAE60_RS20230 (3908065) 3908065..3908889 + 825 WP_001753751.1 DUF2303 family protein -
PAE60_RS20235 (3909076) 3909076..3909858 + 783 WP_000610754.1 hypothetical protein -
PAE60_RS20240 (3909895) 3909895..3910164 + 270 WP_001093912.1 pyocin activator PrtN family protein -
PAE60_RS20245 (3910198) 3910198..3910746 - 549 WP_000019186.1 hypothetical protein Toxin
PAE60_RS20250 (3910769) 3910769..3911242 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
PAE60_RS20255 (3911547) 3911547..3911651 - 105 Protein_3734 tRNA-dihydrouridine synthase -
PAE60_RS20260 (3912014) 3912014..3912754 - 741 WP_001324389.1 DUF2713 family protein -
PAE60_RS20265 (3912749) 3912749..3913030 - 282 Protein_3736 DUF2713 domain-containing protein -
PAE60_RS20270 (3913348) 3913348..3913863 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
PAE60_RS20275 (3913905) 3913905..3914114 - 210 WP_001030593.1 CsbD family protein -
PAE60_RS20280 (3914230) 3914230..3915555 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
PAE60_RS20285 (3915628) 3915628..3916236 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3885451..3916236 30785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T278631 WP_000019186.1 NZ_CP123197:c3910746-3910198 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT278631 WP_000287252.1 NZ_CP123197:c3911242-3910769 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References