Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3793423..3793920 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PAE60_RS19635 Protein ID WP_001173343.1
Coordinates 3793423..3793596 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag PAE60_RS19640 Protein ID WP_001425728.1
Coordinates 3793624..3793920 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS19625 (3790093) 3790093..3791550 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
PAE60_RS19630 (3791787) 3791787..3793304 + 1518 WP_001295074.1 lysine--tRNA ligase -
PAE60_RS19635 (3793423) 3793423..3793596 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PAE60_RS19640 (3793624) 3793624..3793920 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PAE60_RS19645 (3794147) 3794147..3794419 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PAE60_RS19650 (3794431) 3794431..3794661 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PAE60_RS19655 (3794842) 3794842..3796473 + 1632 WP_001216487.1 sensor histidine kinase -
PAE60_RS19660 (3796470) 3796470..3797189 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278630 WP_001173343.1 NZ_CP123197:c3793596-3793423 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT278630 WP_001425728.1 NZ_CP123197:c3793920-3793624 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References