Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2967346..2967964 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PAE60_RS15585 Protein ID WP_001291435.1
Coordinates 2967746..2967964 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PAE60_RS15580 Protein ID WP_000344800.1
Coordinates 2967346..2967720 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS15570 (2962435) 2962435..2963628 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PAE60_RS15575 (2963651) 2963651..2966800 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PAE60_RS15580 (2967346) 2967346..2967720 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PAE60_RS15585 (2967746) 2967746..2967964 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PAE60_RS15590 (2968136) 2968136..2968687 + 552 WP_000102568.1 maltose O-acetyltransferase -
PAE60_RS15595 (2968803) 2968803..2969273 + 471 WP_000136192.1 YlaC family protein -
PAE60_RS15600 (2969437) 2969437..2970987 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PAE60_RS15605 (2971029) 2971029..2971382 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PAE60_RS15615 (2971761) 2971761..2972072 + 312 WP_000409911.1 MGMT family protein -
PAE60_RS15620 (2972103) 2972103..2972675 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278629 WP_001291435.1 NZ_CP123197:2967746-2967964 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278629 WP_000344800.1 NZ_CP123197:2967346-2967720 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References