Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 828770..829395 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAE60_RS05195 Protein ID WP_000911330.1
Coordinates 828997..829395 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PAE60_RS05190 Protein ID WP_000450524.1
Coordinates 828770..828997 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS05165 (824573) 824573..825043 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PAE60_RS05170 (825043) 825043..825615 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PAE60_RS05175 (825761) 825761..826639 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PAE60_RS05180 (826656) 826656..827690 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PAE60_RS05185 (827903) 827903..828616 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PAE60_RS05190 (828770) 828770..828997 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PAE60_RS05195 (828997) 828997..829395 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PAE60_RS05200 (829542) 829542..830405 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PAE60_RS05205 (830420) 830420..832435 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PAE60_RS05210 (832509) 832509..833207 + 699 WP_000679823.1 esterase -
PAE60_RS05215 (833317) 833317..833517 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278621 WP_000911330.1 NZ_CP123197:828997-829395 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278621 WP_000450524.1 NZ_CP123197:828770-828997 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References