Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 4095567..4096372 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag ES15_RS18900 Protein ID WP_014729841.1
Coordinates 4095567..4096094 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag ES15_RS18905 Protein ID WP_014729842.1
Coordinates 4096091..4096372 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS18875 4091443..4091928 + 486 WP_004385735.1 ribonuclease E activity regulator RraA -
ES15_RS18880 4091979..4092218 - 240 WP_007779254.1 septal ring assembly protein ZapB -
ES15_RS18885 4092654..4093505 + 852 WP_007779257.1 aquaporin -
ES15_RS18890 4093524..4095041 + 1518 WP_007779258.1 glycerol kinase GlpK -
ES15_RS18895 4095170..4095532 + 363 WP_004385739.1 YibL family ribosome-associated protein -
ES15_RS18900 4095567..4096094 - 528 WP_014729841.1 GNAT family N-acetyltransferase Toxin
ES15_RS18905 4096091..4096372 - 282 WP_014729842.1 DUF1778 domain-containing protein Antitoxin
ES15_RS18910 4096798..4098453 + 1656 WP_014729843.1 L-lactate permease -
ES15_RS18915 4098450..4099238 + 789 WP_004385742.1 transcriptional regulator LldR -
ES15_RS18920 4099235..4100440 + 1206 WP_014729844.1 FMN-dependent L-lactate dehydrogenase LldD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-148)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19421.38 Da        Isoelectric Point: 9.3306

>T27862 WP_014729841.1 NC_017933:c4096094-4095567 [Cronobacter sakazakii ES15]
MKLKKGVFPFSPEQGWKTAAFDCGCRALNDFLHQRLARQQQRNVLRAYVVITSEPEPAVVGYYTLSGASFEKVLLGDQQR
QIPYASAPCVLLGRLAVDKTFAGRGIGSMLVADAARRVYQVARTIGVYAMFVEAKDEYAAQFYERLGFLPAEGTDGRQRL
FFPVNALATLFPTAE

Download         Length: 528 bp

>T27862 NC_017933:c4096094-4095567 [Cronobacter sakazakii ES15]
ATGAAACTGAAAAAAGGTGTTTTTCCTTTTTCGCCGGAGCAGGGCTGGAAAACCGCCGCGTTCGACTGCGGTTGCCGCGC
GCTTAATGATTTCTTACACCAGCGCCTGGCGCGCCAGCAACAGCGCAATGTCCTGCGCGCTTATGTTGTTATCACGAGCG
AGCCAGAGCCAGCGGTAGTGGGTTATTACACGCTCTCTGGGGCATCTTTCGAAAAAGTGCTGCTGGGCGACCAGCAACGG
CAGATCCCTTATGCGAGCGCCCCCTGCGTTTTACTGGGCAGGTTGGCGGTGGATAAGACATTTGCAGGAAGGGGCATCGG
ATCGATGCTGGTGGCTGATGCAGCAAGGCGAGTTTATCAAGTCGCCCGAACCATAGGTGTCTATGCGATGTTCGTTGAGG
CCAAAGATGAATACGCGGCTCAGTTTTATGAGCGCTTAGGCTTTTTGCCAGCGGAAGGCACCGATGGACGTCAGCGGCTC
TTTTTCCCGGTCAATGCCCTCGCCACATTATTCCCGACGGCAGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10384.56 Da        Isoelectric Point: 4.8605

>AT27862 WP_014729842.1 NC_017933:c4096372-4096091 [Cronobacter sakazakii ES15]
MSASSKKERLEFRLSAEDKAVIEAAASLSGTSVSQFIVDASRARARTLLDEHRRIQLTEQGWQDVMAALDNPPAPNENLK
RAVENLNNGEFWE

Download         Length: 282 bp

>AT27862 NC_017933:c4096372-4096091 [Cronobacter sakazakii ES15]
ATGTCAGCGTCATCGAAAAAAGAGCGCCTTGAGTTTCGCCTCTCAGCCGAGGATAAAGCGGTTATTGAGGCGGCTGCCAG
CCTTTCAGGAACCAGCGTTTCGCAATTCATTGTCGATGCCTCCCGCGCTCGTGCCCGAACGCTGCTTGATGAACACCGCC
GCATTCAGCTAACCGAGCAGGGCTGGCAGGATGTTATGGCTGCGCTGGATAATCCCCCTGCGCCCAATGAAAATCTTAAA
CGTGCTGTTGAAAACCTGAACAACGGCGAATTCTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References