Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 389261..389915 Replicon chromosome
Accession NZ_CP123197
Organism Escherichia coli strain C-SRM-3

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PAE60_RS03100 Protein ID WP_000244777.1
Coordinates 389508..389915 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PAE60_RS03095 Protein ID WP_000354046.1
Coordinates 389261..389527 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE60_RS03070 (384549) 384549..385292 + 744 Protein_374 SDR family oxidoreductase -
PAE60_RS03075 (385349) 385349..386782 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PAE60_RS03080 (386827) 386827..387138 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
PAE60_RS03085 (387302) 387302..387961 + 660 WP_000250274.1 hemolysin III family protein -
PAE60_RS03090 (388038) 388038..389018 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PAE60_RS03095 (389261) 389261..389527 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PAE60_RS03100 (389508) 389508..389915 + 408 WP_000244777.1 protein YgfX Toxin
PAE60_RS03105 (389955) 389955..390476 - 522 WP_001055874.1 flavodoxin FldB -
PAE60_RS03110 (390588) 390588..391484 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PAE60_RS03115 (391509) 391509..392219 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PAE60_RS03120 (392225) 392225..393958 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T278618 WP_000244777.1 NZ_CP123197:389508-389915 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278618 WP_000354046.1 NZ_CP123197:389261-389527 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References