Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3124800..3125419 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name Hha Uniprot ID V5U1U2
Locus tag ES15_RS14540 Protein ID WP_007781479.1
Coordinates 3125201..3125419 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag ES15_RS14535 Protein ID WP_004386908.1
Coordinates 3124800..3125174 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS14525 3119961..3121166 + 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ES15_RS14530 3121188..3124337 + 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit -
ES15_RS14535 3124800..3125174 + 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
ES15_RS14540 3125201..3125419 + 219 WP_007781479.1 hemolysin expression modulator Hha Toxin
ES15_RS14545 3125626..3126177 + 552 WP_014729413.1 maltose O-acetyltransferase -
ES15_RS14550 3126297..3126806 + 510 WP_007891920.1 YlaC family protein -
ES15_RS20410 3126835..3126975 - 141 WP_004386911.1 type B 50S ribosomal protein L36 -
ES15_RS14555 3126979..3127239 - 261 WP_004386912.1 type B 50S ribosomal protein L31 -
ES15_RS14560 3127378..3129279 - 1902 WP_014729414.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8614.02 Da        Isoelectric Point: 9.4828

>T27861 WP_007781479.1 NC_017933:3125201-3125419 [Cronobacter sakazakii ES15]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T27861 NC_017933:3125201-3125419 [Cronobacter sakazakii ES15]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAACTCTACGATAAAATTCCGACCTCCGTGTGGAAGTTCGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT27861 WP_004386908.1 NC_017933:3124800-3125174 [Cronobacter sakazakii ES15]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT27861 NC_017933:3124800-3125174 [Cronobacter sakazakii ES15]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCTGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V5U1U2

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References