Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 82863..83488 Replicon plasmid pEC0430-1
Accession NZ_CP123047
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDU34_RS23625 Protein ID WP_000911333.1
Coordinates 82863..83261 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QDU34_RS23630 Protein ID WP_000450520.1
Coordinates 83261..83488 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS23610 (79194) 79194..79703 + 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -
QDU34_RS23615 (79717) 79717..80448 + 732 WP_000850416.1 conjugal transfer complement resistance protein TraT -
QDU34_RS23620 (80701) 80701..82854 + 2154 WP_000009379.1 type IV conjugative transfer system coupling protein TraD -
QDU34_RS23625 (82863) 82863..83261 - 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QDU34_RS23630 (83261) 83261..83488 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDU34_RS23635 (83570) 83570..84106 + 537 Protein_86 MobF family relaxase -
QDU34_RS23640 (84206) 84206..85414 + 1209 WP_001352368.1 IS4-like element ISVsa5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iucA / iucB / iucC / iucD / iutA / vat / iroN / iroE / iroD / iroC / iroB 1..207503 207503
- flank IS/Tn - - 84206..85414 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T278590 WP_000911333.1 NZ_CP123047:c83261-82863 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT278590 WP_000450520.1 NZ_CP123047:c83488-83261 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References