Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4345988..4346485 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDU34_RS20975 Protein ID WP_001173343.1
Coordinates 4345988..4346161 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDU34_RS20980 Protein ID WP_000398619.1
Coordinates 4346189..4346485 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS20965 (4342658) 4342658..4344115 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
QDU34_RS20970 (4344352) 4344352..4345869 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDU34_RS20975 (4345988) 4345988..4346161 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDU34_RS20980 (4346189) 4346189..4346485 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDU34_RS20985 (4346712) 4346712..4346984 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDU34_RS20990 (4346996) 4346996..4347226 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QDU34_RS20995 (4347407) 4347407..4349038 + 1632 WP_001216486.1 sensor histidine kinase -
QDU34_RS21000 (4349035) 4349035..4349754 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278582 WP_001173343.1 NZ_CP123046:c4346161-4345988 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278582 WP_000398619.1 NZ_CP123046:c4346485-4346189 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References