Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4249492..4250087 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QDU34_RS20475 Protein ID WP_000239579.1
Coordinates 4249492..4249842 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag QDU34_RS20480 Protein ID WP_001223207.1
Coordinates 4249836..4250087 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS20455 (4244768) 4244768..4245790 - 1023 WP_001296689.1 ABC transporter permease -
QDU34_RS20460 (4245804) 4245804..4247306 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
QDU34_RS20465 (4247616) 4247616..4248572 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDU34_RS20470 (4248882) 4248882..4249412 + 531 WP_000055072.1 inorganic diphosphatase -
QDU34_RS20475 (4249492) 4249492..4249842 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QDU34_RS20480 (4249836) 4249836..4250087 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDU34_RS20485 (4250300) 4250300..4250641 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDU34_RS20490 (4250644) 4250644..4254423 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T278581 WP_000239579.1 NZ_CP123046:c4249842-4249492 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT278581 WP_001223207.1 NZ_CP123046:c4250087-4249836 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References