278578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3555525..3556362 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QDU34_RS17205 Protein ID WP_000227784.1
Coordinates 3555820..3556362 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QDU34_RS17200 Protein ID WP_001297137.1
Coordinates 3555525..3555836 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS17175 (3550545) 3550545..3551492 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QDU34_RS17180 (3551514) 3551514..3553505 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QDU34_RS17185 (3553495) 3553495..3554109 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QDU34_RS17190 (3554109) 3554109..3554438 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QDU34_RS17195 (3554450) 3554450..3555340 + 891 WP_000971336.1 heme o synthase -
QDU34_RS17200 (3555525) 3555525..3555836 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QDU34_RS17205 (3555820) 3555820..3556362 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QDU34_RS17210 (3556418) 3556418..3557353 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QDU34_RS17215 (3557761) 3557761..3559125 + 1365 WP_001000975.1 MFS transporter -
QDU34_RS17220 (3559253) 3559253..3559744 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QDU34_RS17225 (3559912) 3559912..3560823 + 912 WP_000705877.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T278578 WP_000227784.1 NZ_CP123046:3555820-3556362 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT278578 WP_001297137.1 NZ_CP123046:3555525-3555836 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References