Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521436..3522054 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDU34_RS17035 Protein ID WP_001291435.1
Coordinates 3521836..3522054 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDU34_RS17030 Protein ID WP_000344800.1
Coordinates 3521436..3521810 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS17020 (3516525) 3516525..3517718 + 1194 WP_128995125.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDU34_RS17025 (3517741) 3517741..3520890 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDU34_RS17030 (3521436) 3521436..3521810 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDU34_RS17035 (3521836) 3521836..3522054 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDU34_RS17040 (3522225) 3522225..3522776 + 552 WP_000102578.1 maltose O-acetyltransferase -
QDU34_RS17045 (3522892) 3522892..3523362 + 471 WP_000136192.1 YlaC family protein -
QDU34_RS17050 (3523526) 3523526..3525076 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDU34_RS17055 (3525118) 3525118..3525471 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDU34_RS17065 (3525850) 3525850..3526161 + 312 WP_000409911.1 MGMT family protein -
QDU34_RS17070 (3526192) 3526192..3526764 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278577 WP_001291435.1 NZ_CP123046:3521836-3522054 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278577 WP_000344800.1 NZ_CP123046:3521436-3521810 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References