Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2355822..2357410 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name hipA Uniprot ID F4NFZ0
Locus tag QDU34_RS11375 Protein ID WP_001125463.1
Coordinates 2356088..2357410 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDU34_RS11370 Protein ID WP_001296726.1
Coordinates 2355822..2356088 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS11370 (2355822) 2355822..2356088 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDU34_RS11375 (2356088) 2356088..2357410 + 1323 WP_001125463.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDU34_RS11380 (2357721) 2357721..2357929 + 209 Protein_2224 AraC family transcriptional regulator -
QDU34_RS11385 (2358363) 2358363..2358926 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QDU34_RS11390 (2359287) 2359287..2359997 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2355822..2372308 16486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49422.05 Da        Isoelectric Point: 9.1203

>T278576 WP_001125463.1 NZ_CP123046:2356088-2357410 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT278576 WP_001296726.1 NZ_CP123046:2355822-2356088 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IYX0

Antitoxin

Source ID Structure

References