Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1339007..1339632 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDU34_RS06535 Protein ID WP_000911330.1
Coordinates 1339234..1339632 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDU34_RS06530 Protein ID WP_000450524.1
Coordinates 1339007..1339234 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS06505 (1334810) 1334810..1335280 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDU34_RS06510 (1335280) 1335280..1335852 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDU34_RS06515 (1335998) 1335998..1336876 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDU34_RS06520 (1336893) 1336893..1337927 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QDU34_RS06525 (1338140) 1338140..1338853 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDU34_RS06530 (1339007) 1339007..1339234 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDU34_RS06535 (1339234) 1339234..1339632 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDU34_RS06540 (1339779) 1339779..1340642 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QDU34_RS06545 (1340657) 1340657..1342672 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
QDU34_RS06550 (1342746) 1342746..1343444 + 699 WP_000679823.1 esterase -
QDU34_RS06555 (1343554) 1343554..1343754 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278570 WP_000911330.1 NZ_CP123046:1339234-1339632 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278570 WP_000450524.1 NZ_CP123046:1339007-1339234 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References